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The Buffalo Bills (10-2) visit the Los Angeles Rams (6-6) hoping to keep the pressure on Kansas City to gain the number one seed in the AFC. Los Angeles is one game out of first place in the NFC West. Our Bills vs Rams prediction is for road favorite Buffalo to cover the 3.5-point spread. The teams will score more than 49.5 points.

Head-to-head, Buffalo leads with a record of 9-5.

Offshore Odds: Buffalo Favored by 3.5 on the Road

TeamSpreadMoney LineTotal
Bills-3.5 (-110)-182O 49.5 (-110)
Rams+3.5 (-110)+162U 49.5 (-110)

Searing Hot Bills Keep the Conference Heat on KC

Buffalo has won seven straight — including a win over the Chiefs — to raise their record to 10-2. If they keep winning and KC slips, Buffalo will take over the number one seed in the AFC, get a first-round bye, and have a clear path to the Super Bowl with home-field advantage throughout the playoffs.

Josh Allen is burnishing his case for NFL MVP every week.

They are second in points scored per game, first in takeaway differential, and sixth in fewest points allowed per game.

This week, ball-hawking veteran safety Micah Hyde was signed to the practice squad where he will prepare for one last run at a Super Bowl. He will retire after the season.

LA is vulnerable to the running game, so expect James Cook, Ray Davis, and Allen himself to establish the run.

A Rams Win Will Move Them Up in the NFC West

Los Angeles still has a good chance to emerge from the muddled NFC West and take the division title. Although they are sitting tied for second place with a .500 record, they are guaranteed to move up if they beat the Bills. Their two rivals, Seattle and Arizona, are playing each other.

Even a Rams loss does not damage them much. Their remaining schedule includes the injury-ravaged 49ers (who might be on the verge of accepting their situation), the Jets, Arizona, and Seattle. In short, they control their destiny.

They are getting healthy with both Cooper Kupp and Puka Nacua back in action. Tight end Tyler Higbee is getting close to a return from a knee injury, but will not play against Buffalo.

On paper, it will be tough for LA to win this game. They are 20th in points scored per game, their running game has been shaky, and they are mediocre defensively. In these circumstances, head coach Sean McVay usually gets aggressive, so expect a high-scoring affair.

Bills vs Rams Prediction: Expect a Relatively Easy Buffalo Win

Ironically, this game is more important to Buffalo than it is to LA despite the Bills clinching the AFC East with five games remaining. LA still has a great shot at the NFC West even with a loss. Buffalo wants to keep the heat on KC and stay ahead of Pittsburgh. They will cover the 3.5-point spread and the total will go over 49.5.

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