Arizona Cardinals vs San Francisco 49ers: Niners Set For Another Showdown (Oct 6)

Our prediction for today’s NFL game between the Cardinals and 49ers is 49ers moneyline -325.

The Arizona Cardinals have been inconsistent, and their offense has struggled in the last two games. The San Francisco 49ers are still dealing with injuries, but they continue to perform like an elite team.

Offshore Odds: 49ers Heavy Favorites

Cardinals vs 49ers Head-to-Head Stats

The Cardinals are 29-36 all-time against the 49ers. San Francisco has won four straight games against the Cardinals and seven of the last ten meetings.

Cardinals Offense Looking To Bounce Back

So far, the Cardinals have been a mystery this season. They had a solid effort against the Bills, blew out the Rams, experienced a somewhat close loss to the Lions, and then were blown out at home by the Commanders.

This team has gone through a bit of everything, and their second-half offense seems to have disappeared. In their last game against the Commanders, the defense allowed ten or more points in three of the four quarters.

Other issues included 82 yards in penalties and allowing Kyler Murray to be sacked four times. They need to return to what worked well in the Rams game: converting on third downs, limiting penalties, getting the offense going from the start, and controlling time of possession.

49ers Defense Ready For Mobile Murray

The 49ers are almost fully healthy, but they are still without their best player, Christian McCaffrey. News broke this week that CMC has Achilles tendinitis in both legs. This injury usually takes six to eight weeks to heal, but it’s uncertain when he will return.

For now, the Niners will continue to rely on their All-Star offensive depth. San Francisco had solid wins against the Jets and Patriots, but they struggled with a poor performance against the Vikings and suffered a complete collapse against the rival Rams.

San Francisco played well against the Patriots, but they could have performed better. They were sloppy on running plays and should converted more in the red zone.

Their defense can be inconsistent against a mobile quarterback, and Murray has certainly made games interesting in the past. Fortunately, the Arizona defense struggled to protect him last week, and the 49ers defense is coming off a game with six sacks.

Cardinals vs 49ers Prediction

The 49ers have a strong track record against the Cardinals, having won the last four meetings easily. The Cardinals will need to keep pace early; otherwise, the game could slowly slip away from them. This could be a close game if San Francisco fails to finish some good drives with touchdowns and if Arizona converts on third downs. Either way, it’s a divisional game, and the 49ers remain the overall better team.

Tags:
• Regular Season (NFL)