For many, this is the final year that the Cardinals will have Kyler Murray as their leader. On the other side, the Bills underwent a small rebuild, which saw them lose Stefon Diggs. This game will tell us plenty about both teams and their possibilities. Also, you can find more NFL picks here.
Before Betting on Cardinals vs. Bills NFL Week 1
We don’t have to tell you that the Cards must be at their best to compete with the Bills here. This is not just because they head to Buffalo, where it’s hard to win, but also because of several injured players, most notably the first-round pick, DL Darius Robinson.
Murray had an injury last season, which separated him from the field for quite some time. He had time to refresh, heal, and focus on football again, but we will see if he changed his diva mentality, which was one of the main problems why he didn’t become an elite QB, yet stayed a solid one.
The Bills made some harsh cuts during the summer. The most painful and frustrating—Stefon Digg’s departure. Josh Allen lost his best and most reliable target, and unfortunately, the team had to do that to keep on chasing the Super Bowl title.
We aren’t sure where the Bills stand right now, and we have to be honest about it. Allen is arguably a top-five quarterback, but will he manage to stay at the same level without Diggs? That’s something to be seen.
Cardinals vs. Bills Head to Head
The previous encounter was in 2020, when the Cardinals edged the Bills in Arizona, 32-30. Overall, the franchise from Buffalo is better than the Cards, having seven wins overall compared to rival’s five.
Cardinals vs. Bills NFL Week 1 Offshore Betting Odds
| Team | Moneyline | Spread | Total |
|---|---|---|---|
| Cardinals | +220 | +6 | 48.5 |
| Bills | -270 | -6 | 48.5 |
Beating the Bills at Highmark Stadium is a very tough task, particularly for average teams like Arizona, which is such one, with all due respect. Allen still has the tools to solve mediocre opponents, and that’s why we pick the home team to triumph.
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