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The Philadelphia Eagles and San Francisco 49ers are going to mix it up on Sunday in the game with the largest point spread of the weekend. The 6-1 Philadelphia Eagles are at home, and their opponent is winless on the season. The 49ers are 0-7, along with the Cleveland Browns. The Philadelphia Eagles are -12 in this game over the San Francisco 49ers.

Eagles Looking to Rule the NFC East

The Philadelphia Eagles are off to a red hot start due in large part to their ability to play well at home, and also score a bunch of points. The Eagles are 3-0 on the season at home, with wins over the New York Giants, Arizona Cardinals and Washington Redskins. In fact, the lone loss for the Eagles this season was on the road at the Kansas City Chiefs, who have just two losses this season.

The Eagles are a great scoring team, as they are scoring more than 28 points per game. The offense may be tested by more than just the San Francisco defense. The forecast in Philadelphia is calling for driving rain, and cold. Carson Wentz has been sensational this season at the quarterback spot. The second year signal caller has thrown for more than 1,850 yards and 17 touchdowns. Zach Ertz is the top receiver, despite playing tight end, with 5 touchdowns, and just shy of 500 yards.

San Francisco Seeking 1st Win of the Season

The San Francisco 49ers were competitive early in the season, but their latest loss to the Cowboys were completely uncompetitive. The 49ers allowed 40 points in the game. On the season, the 49ers defense is allowing teams to score 26.6 points per game, which is 30th in the league. The offense for San Francisco is scoring just 17.6 points per game, which is the 8th fewest in the league

Eagles Crush 49ers at Home

The offense for San Francisco sees Brian Hoyer lead the way for most of the season, but last game, and the starting quarterback in this game is C.J. Beathard. He will lean on Carlos Hyde to run the way, as he has 428 yards on 100 carries and 4 touchdowns. Pierre Garcon is the top receiver, and needs just 17 yards to get to 500 on the season. The 49ers are back home their next three games against the Cardinals, Giants and Seahawks.

While some think that the San Francisco 49ers can compete in this game, there is very little chance of it. The 49ers just are not very talented, and are going to have a tough time scoring points against the Eagles defense. The Philadelphia offense should be able to move the ball and score points pretty much at will. When you are betting this game, take the Philadelphia Eagles as the favorite. Betting the Philadelphia Eagles -12 (at MyBookie) over the San Francisco 49ers is the way to go here.